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Extramural Research

2002 Progress Report: Study of Phthalates in Pregnant Woman and Children

EPA Grant Number: R829436
Title: Study of Phthalates in Pregnant Woman and Children
Investigators: Swan, Shanna H. , Calafat, Antonia , Drobnis, Erma , Lasley, Bill L. , Redmon, Bruce , Sparks, Amy , Wang, Christina
Current Investigators: Swan, Shanna H. , Calafat, Antonia , Kruse, Robin , Lasley, Bill L. , Redmon, Bruce , Sparks, Amy , Wang, Christina
Institution: University of Missouri - Columbia , University of California - Davis , University of California - Los Angeles , University of Iowa , University of Minnesota
Current Institution: University of Rochester , CDC , Harbor-UCLA Medical Center , University of California - Davis , University of Iowa , University of Minnesota , University of Missouri - Columbia
EPA Project Officer: Glenn, Barbara
Project Period: August 1, 2001 through January 31, 2005 (Extended to July 31, 2007)
Project Period Covered by this Report: August 1, 2001 through January 31, 2002
Project Amount: $2,779,164
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001)
Research Category: Economics and Decision Sciences , Endocrine Disruptors

Description:

Objective:

The objective of this research project is to assess the risks posed by environmental phthalate levels to reproductive health by addressing the following issues:

· Does in utero phthalate exposure alter breast and genital development?
· How do infants' pre- and postnatal sensitivity to phthalates compare?
· What are major sources of phthalate exposure for pregnant women and infants?
· Do phthalate metabolite levels vary with ethnicity and geography?
· Do genital and breast measurements vary with ethnicity and geography?
· How is phthalate metabolism altered by pregnancy?

Progress Summary:

During Year 1 of the project, we: (1) piloted all phases of the study; (2) developed all study instruments, protocols, and databases; and (3) examined 94 subjects as of September 28, 2002.

Future Activities:

During Year 2 of the project, we expect to: (1) conduct 275 first visits (in California, Missouri, Minnesota, and Iowa); (2) conduct 125 second visits (in California, Missouri, and Minnesota); (3) use intensive tracing methods to locate subjects that have not responded to telephone calls and initial mailings; (4) begin urinary assays for follicle stimulating hormone; (5) complete at least one manuscript on methods used for physical exam; and (6) obtain descriptive statistics on genital and breast measurements in first 300 subjects, overall and stratified by ethnicity and center.

Journal Articles:

No journal articles submitted with this report: View all 34 publications for this project

Supplemental Keywords:

phthalates, prenatal exposure, sexual development, geography, ethnicity., RFA, Health, Scientific Discipline, Health Risk Assessment, Chemistry, Epidemiology, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, genetic susceptability, Endocrine Disruptors - Human Health, childhood development, infants, metabolites, prenatal exposure, endocrine disrupting chemicals, exposure, exposure studies, sexual development, developmental effects, children, developmental biology, human growth and development, pregnant women, pregnancy, reproductive health, phthalates, epidemiologic studies

Relevant Websites:

http://www.missouri.edu/~sff Exit

Progress and Final Reports:
Original Abstract
2003 Progress Report
2005 Progress Report
2006 Progress Report
Final Report

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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