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Extramural Research

Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood

EPA Grant Number: R827039C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
Investigators: Susser, Ezra , Matte, Thomas , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects

Description:

Objective:

The original two specific aims of this project have not changed and correspond to the two phases of the project. Briefly restated, the aim of the phase 1 project (planned for years 1 and 2), is to evaluate the relation of prenatal polychlorinated biphenyl (PCB) exposure, to be measured in stored maternal sera, to neurodevelopmental outcomes in adolescence based on neuropsychologic, neurologic, behavioral, and psychiatric assessments performed during a previous study. Subjects are a sub-cohort 162 African-Americans from the Collaborative Perinatal Project (CPP) cohort enrolled at Columbia-Presbyterian Medical Center (CPMC). The aim of the phase 2 project is to evaluate the relation of prenatal PCB exposure to neurodevelopmental outcomes at age 39 and over the life course through that age in the same sub-cohort studied in phase 1. Outcomes will be measured by tracing and recruiting subjects to undergo an examination battery designed based on findings from the phase 1 study.

Publications and Presentations:

Publications have been submitted on this subproject: View all 4 publications for this subprojectView all 32 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subprojectView all 25 journal articles for this center

Supplemental Keywords:

RFA, Health, Scientific Discipline, Toxics, Environmental Chemistry, Health Risk Assessment, Epidemiology, pesticides, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Children's Health, genetic susceptability, health effects, pesticide exposure, sensitive populations, health risks, exposure, PCBs, biological response, neurodevelopment, children, Human Health Risk Assessment, neurotoxicity, human exposure, pesticide residues, assessment of exposure, growth and development, neurodevelopmental toxicity, exposure pathways, harmful environmental agents, environmental health hazard, dietary exposure, growth & development, developmental disorders, exposure assessment, neurological development

Progress and Final Reports:
2000 Progress Report
2002 Progress Report


Main Center Abstract and Reports:
R827039    Mount Sinai Center for Children's Environmental Health and Disease Prevention Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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