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Extramural Research

Genetics of Chlorpyrifos Risk in Minority Populations

EPA Grant Number: R827039C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Genetics of Chlorpyrifos Risk in Minority Populations
Investigators: Wetmur, James G. , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health

Description:

Objective:

A molecular genetic research project, closely related to the first three studies, seeks to elucidate the biological mechanisms for individual variation in susceptibility to pesticides. The study will evaluate genotypic and phenotypic heterogeneity in the enzymes that activate and detoxify the oxons of chlorpyrifos and other cholinesterase inhibiting organophosphate pesticides. It will be undertaken using biological samples obtained from the ethnically diverse population of mothers and infants enrolled in the prospective cohort study.

Publications and Presentations:

Publications have been submitted on this subproject: View all 1 publications for this subprojectView all 32 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subprojectView all 25 journal articles for this center

Supplemental Keywords:

infants, exposure, susceptibilty, genetic, enzymes, mechanisms,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Toxics, Geographic Area, Environmental Chemistry, Health Risk Assessment, pesticides, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Physical Processes, Children's Health, health effects, pesticide exposure, sensitive populations, pest management, community-based intervention, exposure, PCBs, biological response, integrated pest management, children, Human Health Risk Assessment, human exposure, pesticide residues, PCB, assessment of exposure, environmental health hazard, dietary exposure, disease, exposure assessment, human health risk, New York (NY), developmental toxicants, environmental hazard exposures

Progress and Final Reports:
2000 Progress Report
2002 Progress Report


Main Center Abstract and Reports:
R827039    Mount Sinai Center for Children's Environmental Health and Disease Prevention Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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