Project Research Results
Main Center: R827039
Grantee Research Project Results
Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban ChildrenEPA Grant Number: R827039C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Center Director: Wolff, Mary S.
Title: Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
Investigators: Berkowitz, Gertrud S. , Matte, Thomas , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Health Effects , Children's Health
Two epidemiologic research projects seek to determine whether pesticides and PCBs have adverse effects on the neurological development of children in the inner city and whether these effects are still evident in adult life. The first of two epidemiologic investigations, closely linked to the Prevention Research Project, is a prospective study of neurodevelopment and health outcomes in relation to antenatal exposures to PCB, chlorpyrifos and other environmental toxicants as well as diet in an ethnically diverse birth cohort of New York City infants delivered at Mount Sinai Hospital. The second epidemiologic investigation is a retrospective cohort study of the relationship between prenatal exposure to polychlorinated biphenyl (PCBs) and neurodevelopmental outcomes in adolescence and adulthood. It will be undertaken in 162 young African American men, now in their 20's and 30's, who have been followed through childhood and adolescence. Their cognitive ability and other domains of neuropsychological status will be re-evaluated in this project. Pre-natal maternal serum samples have been safely stored and will be used to assess pre-natal PCB exposure.Publications and Presentations:
children, exposure, pesticides, PCBs, neurological,, RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, Biochemistry, Children's Health, genetic susceptability, Endocrine Disruptors - Human Health, health effects, sensitive populations, endocrine disrupting chemicals, PCBs, biological response, neurodevelopment, children, Human Health Risk Assessment, neurodevelopmental, neurotoxicity, reproductive development, human exposure, assessment of exposure, neurodevelopmental toxicity, harmful environmental agents, environmentally caused disease, human susceptibility, environmental health hazard, growth & development, developmental disorders, toxics
Main Center Abstract and Reports:
R827039 Mount Sinai Center for Children's Environmental Health and Disease Prevention Research
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides