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Extramural Research

Growth and Development/Evaluation of Carcinogenic Risks

EPA Grant Number: R827027C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827027
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - Columbia University School of Public Health
Center Director: Perera, Frederica P.
Title: Growth and Development/Evaluation of Carcinogenic Risks
Investigators: Perera, Frederica P.
Institution: Columbia University
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2001 (Extended to October 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects

Description:

Objective:

The Research Project on Asthma is designed to achieve Specific Aim 2: to test the hypotheses a) that prenatal and/or postnatal exposure to home allergens (cockroach, house dust mite, and rodent) and ETS, as well as postnatal exposure to PM2.5 and diesel exhaust particulate (DEP), are significant contributors to risk of asthma, as indicated by related biomarkers and persistent wheezing, b) that the risk from home allergens is increased by co-exposure to the air pollutants (ETS, PM2.5 and DEP); and c) that impaired nutritional status (inadequate levels of antioxidants) heightens susceptibility to the pollutants. Project investigators will conduct an etioloic study of environmental and susceptibility factors in the same cohort of 400 infants and will also contribute to the intervention study. The Project will make use of all of the questionnaire data as well as the biomarker data on cotinine and antioxidants collected by the G&D Project. Additional exposures of interest (home allergens, PM2.5 and DEP, and N02 as a potential confounder) will be monitored and modeled. In addition, the Project will obtain measurements of infants' IgE (total and allergen specific) at birth and at 24 months, as well as measurements of lymphocyte proliferation and cytokines at birth. Mothers will be interviewed at serial time points to obtain information on their children's respiratory symptoms. The Co-investigators on this Project will also contribute to the Intervention Research Project by providing the clinical data on respiratory symptoms for the 120 participating infants at enrollment into the intervention (24 months postnatally) and at 30 and 36 months postnatally. They will also provide the IgE analyses at enrollment and at 36 months.

Supplemental Keywords:

children, exposure, asthma, PM, particulate matter, ETS, allergen, infants., RFA, Health, Scientific Discipline, Air, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Environmental Monitoring, Children's Health, genetic susceptability, indoor air, tropospheric ozone, Biology, asthma, dust mite, health effects, sensitive populations, asthma triggers, dust mites, nutrition, copollutants, home, infants, PM 2.5, stratospheric ozone, exposure and effects, diesel particulates, airway disease, exposure, biological response, diesel exhaust particulates, children, diesel exhaust, Human Health Risk Assessment, airway inflammation, human exposure, inhalation, children's vulnerablity, assessment of exposure, childhood respiratory disease, PM, epidemeology, biological markers, indoor air quality, sensitive population, dust , human health, allergic response, allergen, disease, exposure assessment, human health risk, indoor environment, respiratory, toxics, maternal exposure, cockroaches

Progress and Final Reports:
2000 Progress Report
2001 Progress Report
2002 Progress Report


Main Center Abstract and Reports:
R827027    CECEHDPR - Columbia University School of Public Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827027C001 Community-Based Intervention: Reducing Risks of Asthma
R827027C002 Growth and Development/Evaluation of Carcinogenic Risks
R827027C003 Research Project on Asthma

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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