Project Research Results
Main Center: R826711
Grantee Research Project Results
Role of RSV Infection and Endotoxin in Airway InflammationEPA Grant Number: R826711C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R826711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Iowa Children's Environmental Airway Disease Center
Center Director: Hunninghake, Gary W.
Title: Role of RSV Infection and Endotoxin in Airway Inflammation
Investigators: Schwartz, David , Hunninghake, Gary W.
Current Investigators: Hunninghake, Gary W. , Schwartz, David
Institution: University of Iowa
EPA Project Officer: Fields, Nigel
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Provision of optimal medical management of childhood asthma in the rural setting is a particular challenge because of limited health care, high rates of poverty, fewer children with health insurance, and unique environmental exposures that are difficult to control. In rural communities, children commonly are exposed to organic dusts, agricultural chemicals, animal allergens, and grain dust mites that are brought into the home on work clothing. Moreover, for children in rural settings, the farm is their home, playground, and workplace, with children as young as five years of age participating in farm chores. There is now convincing evidence that a community-based, multi-component intervention approach is the best route to prevent and control childhood asthma. The overall hypothesis of this study is that environmental intervention is an essential component of an asthma intervention program that must be coordinated with other improvements in health care to reduce the prevalence and severity of asthma among rural children. The goal of this study is therefore to develop, implement, and test a community-based, multi-component model for the prevention of asthma among rural children. Publications and Presentations:
children, health, asthma, intervention., RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, genetic susceptability, Atmospheric Sciences, Biology, asthma, health effects, rural communities, sensitive populations, endotoxin, airway disease, allergic airway, respiratory problems, biological response, children, interluken, airway inflammation, interleukin, mitogem activated protein kinase, etiology, gene expression, human exposure, inhalation, children's vulnerablity, assessment of exposure, childhood respiratory disease, agricultural community, disease, exposure assessment, genetic susceptibility
Progress and Final Reports:
Main Center Abstract and Reports:
R826711 University of Iowa Children's Environmental Airway Disease Center
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826711C001 Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
R826711C002 Multi-component Intervention Study of Asthma in Children from Rural Communities
R826711C003 Role of RSV Infection and Endotoxin in Airway Inflammation
R826711C004 A Model to Study the Development of Persistent Environmental Airway Disease