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Extramural Research

Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation

EPA Grant Number: R826711C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: University of Iowa Children's Environmental Airway Disease Center
Center Director: Hunninghake, Gary W.
Title: Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
Investigators: Schwartz, David , Nauseef, William
Current Investigators: Nauseef, William , Denning, Gerene , Hunninghake, Gary W. , Moreland, Jess , Schwartz, David , Weiss, Jerry
Institution: University of Iowa
EPA Project Officer: Fields, Nigel
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects

Description:

Objective:

Airway inflammation reflects a complex and orchestrated series of events, including direct and cytokine-mediated intercellular interactions, which culminate in tissue injury. The inflammation following respiratory challenge with grain dust (GD) elicits a spectrum of clinical responses, from acute and self-limited "grain fever" to chronic airway disease. Epidemiologic studies implicate chronic inhalation of grain dust as a major cause of clinically significant, irreversible airway disease. Although GD is contaminated with bacterial lipopolysaccharide (LPS), not all of the observed responses are attributable to LPS. The overall hypothesis in this study is that mechanisms that initiate, promote, and resolve grain dust induced inflammation may be distinct from those mechanisms involved in LPS induced airway inflammation. We will examine the mechanisms responsible for the initiation, promotion, and resolution of LPS/GD-induced inflammation in order to understand better the pathogenesis of asthma in children from rural communities.

Publications and Presentations:

Publications have been submitted on this subproject: View all 14 publications for this subprojectView all 33 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 14 journal articles for this subprojectView all 32 journal articles for this center

Supplemental Keywords:

children, health, asthma, grain dust, rural communities., RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Environmental Chemistry, Health Risk Assessment, Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, genetic susceptability, Biology, Risk Assessment, asthma, health effects, rural communities, sensitive populations, cytokines, airway disease, exposure, biological response, LPS, children, Human Health Risk Assessment, airway inflammation, tissue reactivity, human exposure, children's vulnerablity, assessment of exposure, childhood respiratory disease, harmful environmental agents, epidemeology, environmentally caused disease, grain dust, mechanisms, lipopolysaccaride, agricultural community, allergen, exposure assessment, human health risk

Progress and Final Reports:
2000 Progress Report
Final Report


Main Center Abstract and Reports:
R826711    University of Iowa Children's Environmental Airway Disease Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826711C001 Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
R826711C002 Multi-component Intervention Study of Asthma in Children from Rural Communities
R826711C003 Role of RSV Infection and Endotoxin in Airway Inflammation
R826711C004 A Model to Study the Development of Persistent Environmental Airway Disease

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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