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Extramural Research

Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)

EPA Grant Number: R826710C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826710
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Michigan Center for the Environment and Children’s Health
Center Director: Israel, Barbara A.
Title: Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
Investigators: Israel, Barbara A. , Robbins, Tom
Current Investigators: Israel, Barbara A. , Brown, Randall , Keeler, Gerald J. , Lin, Xihong , Parker, Edith , Philbert, Martin , Remick, Daniel , Robbins, Tom
Institution: University of Michigan - Ann Arbor
EPA Project Officer: Saint, Chris
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects



The prevalence of asthma has increased markedly over the past fifteen years. It is the most common chronic disease of childhood in the developed world, affecting about 10 million U.S. children under the age of 16. Asthma is most common among urban and minority populations. The causes of these increases and the greater risk for urban, minority populations are not well understood. The causation, and aggravation, of childhood asthma is complex and involves many factors including genetic disposition, demographic variables, psychosocial stresses, and environmental exposures. Environmental exposures include both ambient (outdoor) exposures as well as indoor exposures within the home and at school. The first specific aim of the Asthma Exposure research project is to determine the prevalence of questionnaire defined asthma among the elementary age school children in African-American and Latino populations in Detroit. Students and their families from 10 to 12 elementary schools (approximately 6000 students) in two areas in which the investigators have pre-existing strong community ties, i.e., southwest Detroit and the east side of Detroit, will be asked to complete a short, well validated asthma screening questionnaire. The second specific aim is to identify which components of the outdoor air, of indoor air contaminants, and family and neighborhood characteristics are associated with increased risk for asthma in this population. The third specific aim is to examine whether seasonal and daily changes in outdoor air pollution and indoor air contaminants explain fluctuations in the severity of asthma. The last specific aim is to provide ambient (community/neighborhood level), micro-environmental (inside schools and homes), and personal monitoring data to investigate the relationships between various exposure metrics and activity patterns of asthmatic children living in the southwest and eastsides of Detroit. This approach will improve on the design of prior studies by collecting detailed multiple daily measures of ambient air contaminants together with comprehensive assessment of indoor air contaminants in households and schools and individual family and neighborhood measures of psychosocial factors, and assessing the association of these with a comprehensive set of health status measures, including lung function testing (FEV1), also collected on a daily basis.

Publications and Presentations:

Publications have been submitted on this subproject: View all 3 publications for this subprojectView all 45 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subprojectView all 22 journal articles for this center

Supplemental Keywords:

children, health, asthma, exposure, home, indoor air., RFA, Health, Scientific Discipline, Air, Geographic Area, Environmental Chemistry, Health Risk Assessment, Epidemiology, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, genetic susceptability, indoor air, Biology, Gulf of Mexico, asthma, health effects, sensitive populations, urban air, minority population, school based study, African American, airway disease, exposure, biological response, latino, outdoor air, children, Human Health Risk Assessment, airway inflammation, lung function testing, inhalation, minorities, children's vulnerablity, assessment of exposure, childhood respiratory disease, epidemeology, indoor air quality, air quality, exposure assessment, human health risk, indoor environment, Michigan (MI), toxics, environmental hazard exposures

Progress and Final Reports:
1999 Progress Report
2000 Progress Report
2002 Progress Report

Main Center Abstract and Reports:
R826710    Michigan Center for the Environment and Children’s Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826710C001 Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
R826710C002 Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)
R826710C003 A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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