A Nonsteady State Model for the Tight-Binding Inhibition of Thymidylate Synthetase By 5-Fluorouracil

5-Fluorouracil (5_FU) is a widely used chemotherapeutic drug and tratogen that was chosen as a prototypic toxicant to contruct a biologically based dose-resonse (BBDR) model (Setzer et. al., 2001). Part of the BBDR model simulates the inhibition of thymidylate synthetase (TS), and esential enzyme for DNA synthesis. TS methylates deoxyuridine monophosphate (dUMP) to form thymidine monophosphate (dTMP). A metabolite of 5-FU, fluorode

Citation

DeWoskin, R S. AND R W. Setzer. A Nonsteady State Model for the Tight-Binding Inhibition of Thymidylate Synthetase By 5-Fluorouracil. Presented at Society of Toxicology, Salt Lake City, Utah, March 9-13, 2003.