IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft)
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Abstract
EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 1,1,2,2-tetrachloroethane that will appear on the Integrated Risk Information System (IRIS) database.
The draft Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.
The draft Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.
Impact/Purpose
The draft Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane.
Status
Following External Peer Review, the final assessment is scheduled to be posted to the IRIS database.
Citation
U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001, 2009.
History/Chronology
| Date | Description |
|---|---|
| Mar 1987 | An assessment for 1,1,2,2-tetrachloroethane is currently available on IRIS and contains a carcinogenicity assessment last revised in 1994. |
| 2003 | 1,1,2,2-tetrachloroethane was nominated for reassessment by the Office of Air and Radiation/OAQPS and Region 4. |
| Sep 2009 | EPA releases an external review draft of the assessment for public review and comment. |
| Dec 2009 | EPA announces an external peer review workshop to be held on January 27, 2010 in a December 17, 2009 Federal Register Notice. |
| Feb 2010 | EPA releases the comments from the public comment period and external review workshop. |
Additional Information
Comments on the assessment were submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0115 (for the docket ID).