IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft)

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EPA is releasing the draft report,Toxicological Review for Carbon Tetrachloride, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.


This assessment has been loaded into the IRIS Web site and Database.


U.S. EPA. IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/005D, 2010.


May 2008EPA released the external review draft for public comment. [Federal Register Notice May 21, 2008]
Jun 2008EPA announced a public listening session on July 16, 2008. [Federal Register Jun 24, 2008 ]
Sep 2008EPA announced the external peer review meeting to be held on October 14, 2008. [Federal Register Sep 9, 2008]
Nov 2008EPA released the comments from the external review workshop.
Nov 2009EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Carbon Tetrachloride.
Mar 2010EPA released the Toxicological Review and IRIS Summary for Carbon Tetrachloride and the interagency review draft with interagency review comments.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.