Framework for Application of the Toxicity Equivalence Methodology for Polychlorinated Dioxins, Furans and Biphenyls in Ecological Risk Assessment (External Review Draft)

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Abstract

Polychlorinated dioxins (PCDDs), furans (PCDFs), and biphenyls (PCBs) are persistent contaminants found widely in the environment. Several of these compounds bioaccumulate in the tissues of fish, birds, and mammals, where they have been demonstrated to cause mortality and adverse effects on reproduction, development, and the immune system. This Framework is intended to assist EPA scientists in using a method known as the toxicity equivalence methodology to assess ecological risks from mixtures of these compounds. The Framework also informs EPA decision makers, other agencies, and the public about this methodology.

This framework is not a regulation nor is it intended to substitute for federal regulations.


Citation

U.S. EPA. Framework for Application of the Toxicity Equivalence Methodology for Polychlorinated Dioxins, Furans and Biphenyls in Ecological Risk Assessment (External Review Draft). U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC, 630/P-03/002A, 2003.