EVIDENCE FOR EFFECTS OF CHRONIC LEAD EXPOSURE ON BLOOD PRESSURE IN EXPERIMENTAL ANIMALS: AN OVERVIEW
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
Information obtained in a number of experimental studies conducted over the last forty years on the effects of lead on blood pressure is reviewed. Differences in animal species, age at beginning of exposure, level of lead exposure, indices of lead burden, and blood pressure effects of each study are reported. In several of the high-dose experiments, hypertension was observed, but nephrotoxicity of lead may have contributed to its development. Moreover, in other high-dose experiments, no hypertension was observed and in at least one, the evidence suggested that lead could reduce an elevated blood pressure. In contrast, the lower-dose experiments consistently demonstrated a hypertensive effect. Overall, the data suggest a biphasic dose response.
Citation
Victery, W. EVIDENCE FOR EFFECTS OF CHRONIC LEAD EXPOSURE ON BLOOD PRESSURE IN EXPERIMENTAL ANIMALS: AN OVERVIEW. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-88/018.