Health Assessment Document for 1,1,1-Trichloroethane (Methyl Chloroform). Final Report

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1,1,1-Trichloroethane , or commonally referred to as Methyl chloroform (MC), is a volatile chlorinated hydrocarbon used extensively as an industrial solvent and in consumer products. It has been detected in the ambient air of a variety of urban and non-urban areas of the United States. In certain instances involving contamination of groundwater, much higher levels have been reported.

The weight of available evidence obtained from both human and animal data suggest that long-term exposure to environmental levels of MC poses no serious health concern to the general population. No teratogenic potential has been demonstrated for MC in studies conducted to date in rodent species. Available data are inadequate for reaching firm conclusions about its mutagenic potential in humans. Because of the limited usefulness of the animal bioassays conducted to date, it is not possible to classify MC in regard to its carcinogenic potential in humans.


Carchman, R., I. Davidson, M. Greenberg, J. Parker, AND V. Benignus. Health Assessment Document for 1,1,1-Trichloroethane (Methyl Chloroform). Final Report. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-82/003F (NTIS PB84183565).

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