Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons
PAHs are products of incomplete combustion of organic materials; sources are, thus, widespread,including cigarette smoke, municipal waste incineration, wood stove emissions, coal conversion, energy production form fossil fuels, and automobile and diesel exhaust. As PAHs are common environmental contaminants, it is important that EPA have a scientifically justified, consistent approach to the evaluation of human health risk from exposure to these compounds. For the majority of PAHs classified as B2, probable human carcinogens, data are insufficient for calculation of an inhalation or drinking water unit risk. Benzo[a]pyrene (BAP) is the most completely studied of the PAHS, and data, while problematic, are sufficient for calculation of quantitative estimates of carcinogenic potency. Toxicity Equivalency Factors (TEF) have been used by U.S. EPA on an interim basis for risk assessment of chlorinated dibenzodioxins and dibenzofurans. Data for PAHs do not meet all criteria for use of TEF. This document presents a somewhat different approach to quantitative estimation for PAHs using weighted potential potencies. These estimates are recommended only for evaluation of risk from oral exposure and are proposed only for the assessment of potential carcinogenicity of PAHS.
Schoeny, R. AND K. Poirier. Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons. U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Washington, DC, EPA/600/R-93/089 (NTIS PB94116571).
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