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The Office of Health and Environmental Assessment of the Office of Research and Development has prepared this health assessment document (HAD) at the request of the Office of Air Quality Planning and Standards. Hexachlorocyclopentadiene (HEX) is an intermediate in the pesticide and flame retardant manufacturing processes and is currently being studied by the Environmental Protection Agency (EPA) to determine if it should be regulated as a hazardous air pollutant under the Clean Air Act. The scientific literature and key studies have been reviewed and evaluated and summaries and conclusions have been directed at the health effects from exposure to HEX. This peer-reviewed document contains information on HEX covering toxicity, environmental fate and transport, aquatic effects, mutagenicity, epidemiology, teratogenicity and other health effects data. The data base is neither extensive nor adequate for assessing the carcinogenicity or long-term health effects of acute or low-level chronic exposure to HEX.
Reisman, D. Health Assessment Document for Hexachlorocyclopentadiene. Final Report. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/8-84/001F (NTIS PB85124915).