Health and Environmental Effects Profile for Chlorpyrifos and Chlorpyrifos-Methyl

The Health and Environmental Effects Profile for chlorpyrifos and chlorpyrifos methyl was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. Chlorpyrifos and chlorpyrifos methyl have been determined to be systemic toxicants. An Acceptable Daily Intake (ADI), defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime) without suffering a deleterious effect, for chloropyrifos is .01 (mg/kg bw/day) and for chlorpyrifos methyl is .01 (mg/kg bw/day) for oral exposure.


U.S. EPA. Health and Environmental Effects Profile for Chlorpyrifos and Chlorpyrifos-Methyl. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/X-84/331 (NTIS PB88161955), 1984.