Health Assessment Document for Tetrachloroethylene (Perchloroethylene)
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Tetrachloroethylene has not been clearly demonstrated to cause point mutations in bacteria, but it may be genetically active in yeast. The potential of PERC to produce adverse teratogenic or reproductive effects is, at present, undetermined. Of special concern is the observation that PERC is preferentially concentrated in maternal milk. Thus, nursing infants may represent a special risk group. Both acute and chronic exposure levels have the potential to cause liver damage in humans.
In animals, the lowest observable adverse effect level is 100 ppm. However, this may not be sufficiently protective of human health with regard to liver and kidney toxicity.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
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