Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft)
[UPDATE] EPA has extended the public comment period 60 more days. At the request of the American Chemistry Council, the public comment deadline is extended to January 13, 2014. [Federal Register Notice November 13, 2013
EPA announces the release of the draft report, Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft) in a September 30, 2013 Federal Register Notice. This draft report is provided for public viewing and comment. Public comments received on the draft report within 45 days after the release of the FRN will be considered by EPA in their revisions. The deadline for comments is November 14, 2013.
EPA is releasing a draft report "Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology" that explores how new molecular, computational and systems biology data and approaches (together called "NexGen") could better inform risk assessment. The report summarizes the state of the science and provides prototypes, which are case studies that use available NexGen information. This draft report will be available for public review and comment and will undergo independent external peer review.
|Feb 2010||EPA initiated a Next Generation Risk Assessment (NexGen) program to identify and evaluate recent advances in biological and computational sciences and explore how new data and approaches might be used in risk assessment.|
|Nov 2010||EPA convened a three day expert scientist workshop, called "Advancing the Next Generation (NexGen) of Risk Assessment: The Prototype Workshop," on November 1–3, 2010, in Research Triangle Park, North Carolina. The event was set up to discuss a draft framework, early draft prototypes, research, and other program elements. See the Prototype Workshop Summary Report (PDF, 34 pp, 547Kb).|
|Feb 2011||EPA sponsored a Public Dialogue Conference in Washington, DC, called "Advancing the Next Generation (NexGen) of Risk Assessment." This event engaged the public in the early stages of the NexGen program, help invitees share information, and EPA receive feedback. See the Public Dialogue Conference Summary Report (PDF, 33 pp, 476Kb).|
|Jun 2012||EPA supported and provided NexGen program speakers for an NRC convened workshop (called "Systems Biology – Informed Risk Assessment”) on June 14-15, 2012, in Washington, DC, to discuss emerging sciences in systems biology as tools to inform risk assessment and decision-making and to identify what key issues must be addressed.|
|Sep 2013||EPA releases the draft report, Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology for public review and comment and external peer review. [Federal Register Sep 30, 2013]|
|Nov 2013||EPA extended the public comment deadline 60 more days, the new deadline for comments is January 13, 2014. [Federal Register Notice Nov 13, 2013.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (142 pp, 4 MB, about PDF)