IRIS Toxicological Review of Biphenyl (Interagency Science Discussion Draft)
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Biphenyl is an organic compound that forms colorless crystals. It occurs naturally in coal tar, crude oil, and natural gas. Biphenyl was once used in the production of polychlorinated biphenyls (PCBs) before they were banned in the late 1970s. It is no longer used as an antimicrobial and a fungicide in the U.S., but it is still used as a fungistat in other countries, most commonly in the packaging of citrus fruits. Today, biphenyl is mainly used in the production of pesticides, as a dye carrier in polyester dyeing, and as a component of heat transfer fluids, which are used for industrial processing applications. Biphenyl is found at multiple Superfund sites and other hazardous waste sites. It is on the list of Hazardous Air Pollutants (HAPs) and is classified as one of the High Production Volume (HPV) chemicals.
|Aug 1989||The RfD for Biphenyl was posted to the IRIS Database.|
|Mar 1991||The cancer assessment for Biphenyl was posted to the IRIS database.|
|Sep 2011||EPA hosted an interagency science consultation on the review of the draft Toxicological Review of Biphenyl.|
|Sep 2011||EPA released the external review draft of the biphenyl assessment for public review and comment. [Federal Register Notice Sep 30, 2011]|
|Apr 2012||The external peer review workshop was held.|
|Jun 2012||EPA released the comments from the public comment period and external peer review workshop.|
|May 2013||EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Biphenyl and IRIS Summary for Biphenyl.|
|Aug 2013||EPA released the final IRIS Toxicological Review of Biphenyl and IRIS Summary for Biphenyl, along with the interagency science discussion draft, interagency comments, and EPA’s response to interagency comments.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.