IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (Interagency Science Discussion Draft)
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Abstract
1,4-Dioxane is commonly used as a solvent, cleaning agent, chemical stabilizer, surface coating, adhesive agent, and an ingredient in chemical manufacture. The IRIS Program completed the assessment for oral exposure to 1,4-dioxane on August 11, 2010 and noted that new inhalation studies would be evaluated separately. The 2010 oral assessment has now been updated with additional information regarding 1,4-dioxane toxicity following exposure via inhalation resulting in the 2013 1,4-dioxane assessment (with inhalation update).
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
Aug 2010 | EPA released the final oral toxicity assessment of 1,4-dioxane on the IRIS Web site. |
May 2011 | EPA initiated the interagency science consultation on the draft Toxicological Review of 1,4-Dioxane. |
Sep 2011 | EPA released the external review draft of the 1,4-dioxane assessment (with inhalation update) for public review and comment. EPA concurrently released the interagency science consultation draft toxicological review and charge, and interagency comments with EPA's response. |
Jul 2013 | EPA initiated the final agency review and interagency science discussion on the draft Toxicological Review of 1,4-Dioxane (with inhalation update) and draft IRIS Summary. |
Sep 2013 | EPA released the final IRIS Toxicological Review of 1,4-Dioxane (with inhalation update) and IRIS Summary for 1,4-Dioxane along with the interagency science discussion draft, interagency comments, and EPA's response to interagency comments. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- IRIS Toxicological Review of 1,4-Dioxane (with inhalation update) (Interagency Science Discussion Draft) (Jun 2013) (PDF) (364 pp, 4 MB, about PDF)
- IRIS Summary for 1,4-Dioxane (with inhalation update) (Interagency Science Discussion Draft) (Jun 2013) (PDF) (26 pp, 244 KB, about PDF)
- EPA’s Response to Major Interagency Science Discussion Comments (PDF) (4 pp, 58 KB, about PDF)
- 1. CDC ATSDR Comments on 1,4-dioxane(with inhalation update) (PDF) (2 pp, 52 KB, about PDF)
- 2. CEQ IASD Comments on 1,4-dioxane(with inhalation update) (PDF) (1 pp, 40 KB, about PDF)
- 3. DoD IASD Comments on 1,4-dioxane Tox Review (with inhalation update) (PDF) (7 pp, 74 KB, about PDF)
- 4. DoD IASD Comments on 1,4-dioxane IRIS Summary (with inhalation update) (PDF) (2 pp, 50 KB, about PDF)
- 5. NIOSH IASD Comments on 1,4-dioxane (with inhalation update) (PDF) (2 pp, 48 KB, about PDF)
- 6. OMB and OSTP IASD Comments on 1,4-dioxane (with inhalation update) (PDF) (1 pp, 49 KB, about PDF)
Related Link(s)
- IRIS Summary for 1,4-dioxane (2013 Final) (PDF) (32 pp, 291 KB, about PDF)
- IRIS Toxicological Review of 1,4-Dioxane (with Inhalation Update) (External Review Draft)
- IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)
- IRIS Toxicological Review of 1,4-Dioxane (With Inhalation Update) (Final Report)