Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment
Notice The U.S. EPA has released the final status report entitled Advances in Inhalation Gas Dosimetry for Derivation of a Reference Concentration (RfC) and Use in Risk Assessment.
The RfC Methods document (Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry; EPA/600/8-90/066F, October 1994) provides the basis for EPA extrapolation of data from animal toxicology studies to estimate delivered dose in humans as part of the development of inhalation reference values (i.e., RfC values). This report evaluates and summarizes the pertinent scientific developments and advancements in gas dosimetry focusing on extrathoracic (ET) or upper respiratory tract (URT), tracheobronchial (TB), pulmonary (PU), and extrarespiratory (systemic, SYS) effects as they relate to the current methodology used by EPA. Particular emphasis is placed on the use of data from animal studies to estimate a comparable dose in humans for inhaled chemicals. In addition, this report summarizes available data pertaining to inhalation dosimetry throughout the respiratory tract of children as it relates to derivation of an RfC. This report provides the scientific foundation necessary for ensuring that methods and guidance used and implemented by EPA in inhalation risk assessment of gases reflects the state of the science.
|Apr - Jun 2012||Internal EPA workgroup review and management review.|
|Jul 2012||Revised report submitted to independent, external peer review.|
|Aug 2012||Revised final report based on peer review panel's comments.|
|Sep 2012||EPA released the final report.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (145 pp, 2 MB, about PDF)
- Methods for Derivation of Inhalation Reference Concentrations (RfCs) and Application of Inhalation Dosimetry
- 2009 Status Report: Advances in Inhalation Dosimetry of Gases and Vapors with Portal of Entry Effects in the Upper Respiratory Tract
- 2011 Status Report: Advances in Inhalation Dosimetry for Gases with Lower Respiratory Tract and Systemic Effects