IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft)

Overview
History
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Archive disclaimer
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Abstract

EPA is releasing the draft report, Toxicological Review of Dichloromethane, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane. Dichloromethane, also known as methylene chloride, is a colorless liquid. It is, or has been, used principally in paint strippers and removers, as a propellant in aerosols, in the manufacture of drugs, pharmaceuticals, film coatings, electronics, and polyurethane foam, as a metal cleaning solvent, and in the decaffeination process of coffee and tea.

Impact/Purpose

The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane.

Status

This assessment has been loaded into the IRIS Web site and Database.

Citation

U.S. EPA. IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/003D, 2011.

History/Chronology

Date	Description
03-Dec 2009	EPA hosted an interagency science consultation on the draft Toxicological Review of Dichloromethane.
04-Mar 2010	EPA released the external review draft for public comment. EPA also announced a public listening session on May 11, 2010. [Federal Register Mar 31, 2010]
05-Aug 2010	EPA announced the external peer review meeting to be held on September 23, 2010. [Federal Register Aug 17, 2010]
06-Nov 2010	EPA released the comments from the external review workshop.
07-Aug 2011	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Dichloromethane.
08-Nov 2011	EPA released the final Toxicological Review and IRIS Summary for Dichloromethane and the interagency review draft with interagency review comments.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

IRIS Toxicological Review of Dichloromethane (Interagency Science Discussion Draft) (PDF) (584 pp, 5 MB, about PDF)
Dichloromethane Summary (Interagency Science Discussion Draft) (PDF) (32 pp, 268 KB, about PDF)
EPA's Response & Interagency Science Discussion Comments (PDF) (7 pp, 50 KB, about PDF)
1. DOD DCM IASD Comments (PDF) (3 pp, 38 KB, about PDF)
2. NIEHS NTP DCM IASD Comments (PDF) (1 pp, 40 KB, about PDF)
3. OMB DCM IASD Comments (PDF) (6 pp, 49 KB, about PDF)

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