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Risk Assessment

Guidelines for the Health Risk Assessment of Chemical Mixtures

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.


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The 1986 Guidelines for the Health Risk Assessment of Chemical Mixtures represent the Agency's science policy and are a procedural guide for evaluating data on the health risks from exposures to chemical mixtures. The emphasis is on dose response and risk characterization.


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