IRIS Toxicological Review of Chlordecone (Interagency Science Discussion Draft)
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The draft Toxicological Review of chlordecone provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to chlordecone. Chlordecone is a chlorinated insecticide which was used mainly as a fungicide and insecticide to control slugs, snails, and fire ants. According to the CERCLA database, chlordecone is found at 3 National Priority List (NPL) Superfund sites. Intoxication occurred in over a hundred workers at a Hopewell, Virginia, chlordecone manufacturing plant in the late 1970s. Effects observed in the workers following this accident included tremors, liver enlargement, and oligospermia (low semen volume). Registration was cancelled in 1978.
|2004||EPA began developing the Toxicological Review of chlorodecone.|
|Jan 2008||EPA released an External Review Draft for public comment and review.|
|Aug 2009||EPA hosted an interagency science discussion on the draft IRIS Summary and Toxicological Review of chlordecone. These comments are provided on this web site.|
|Sep 2009||EPA released the Final Toxicological Review (PDF) and accompanying Summary for chlordecone to the IRIS Web site.|
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