IRIS Toxicological Review of Pentachlorophenol (External Review Draft)

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EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of pentachlorophenol that will appear in the Integrated Risk Information System (IRIS) database.

The draft Toxicological Review of Pentachlorophenol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to pentachlorophenol. Pentachlorophenol is a wood preservative used to prevent decay from fungal organisms and insect damage. Use by the public was restricted in 1984, and application was limited to industrial areas. It has been reported in food, surface water, groundwater, rainwater, and soil. People who work or reside in close proximity to wood treatment facilities, treated lumber, or hazardous waste sites are likely exposed.

This assessment contains a revised oral reference dose (RfD) for chronic noncancer health effects as well as a revised oral cancer risk estimate.


Following the External Peer Review, the final assessment will be published on the IRIS database.


U.S. EPA. IRIS Toxicological Review of Pentachlorophenol (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/004, 2009.


Jan 1987EPA posted the pentachlorophenol assessment on the IRIS database (RfD only).
Mar 1991EPA posted the carcinogenicity assessment for oral exposure to pentachlorophenol on the IRIS database.
May 2009EPA released an updated draft report for public review and comment.
Jun 2009EPA announced a public listening session for the draft review report.
Jun 2009EPA announced a external peer review meeting to be held August 4th in Arlington, VA.
Oct 2009EPA releases the comments from the public comment period and external review workshop.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2009-0178 (for the docket ID) to comment on this report.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.