Physiological Parameters Database for PBPK Modeling (External Review Draft)
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The PBPK Modeling Database is available for download as a compressed Microsoft ACCESS file. To open the compressed file, first save the file on your hard drive, and unzip the contents into a folder of your choosing.
Physiologically-based pharmacokinetic (PBPK) models have increasingly been employed in chemical health risk assessments carried out by the U.S. Environmental Protection Agency (EPA), and it is anticipated that their use will continue to increase. Because relevant physiological parameter values (e.g. alveolar ventilation, blood flow and tissue volumes, glomerular filtration rate) are critical components of these models but are scattered among various sources in the scientific literature, EPA has fostered several efforts to compile these data into an electronic relational database that is intended to be suitable for use by researchers and risk assessors.
As an important class of dosimetry models, PBPK models are useful for predicting internal dose at target organs for risk assessment applications. Dose-response relationships that appear unclear or confusing at the administered dose level can become more understandable when expressed on the basis of internal dose of the chemical. To predict internal dose level, PBPK models use physiological data to construct mathematical representations of biological processes associated with the absorption, distribution, metabolism, and elimination of compounds. With the appropriate data, these models can be used to extrapolate across species, lifestages, and exposure scenarios, as well as address various sources of uncertainty in risk assessments. This database contains a collection of physiological data relevant for parameterizing PBPK models for children, adults, and the elderly. In addition, the database contains physiological data for parameterizing PBPK models for young (i.e., developing) and adult rodents.
|2005||EPA released a Request for Proposals (RFQ PR-DC-05-01981) to develop a database of physiological parameters in the aged/elderly population.|
|2006||An ACCESS database was delivered under an independent contract and subsequently modified by EPA prior to its current release.|
|Feb 2008||EPA released the Physiological Parameters Database for Older Adults (Beta 1.0) to the public for review and comment.|
|Dec 2008||EPA released a revised Physiological Parameters Database for Older Adults (Beta 1.1) to the public for review and comment.|
|Apr 2009||EPA released a revised Physiological Parameters Database to the public for review and comment.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.