IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

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EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

The draft Toxicological Review of Hydrogen Cyanide and Cyanide Salts provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to hydrogen cyanide and cyanide salts. Cyanide compounds are used in a number of industrial processes including mining, electroplating, metallurgy, chemical manufacturing, and photography because these compounds can form stable complexes with a range of metals. Hydrogen cyanide is also a component of tobacco smoke, vehicle exhaust, and is produced by the burning of some plastics. Cyanide salts, such as potassium and sodium cyanide, are also used as rodenticides.


Following the External Peer Review, the final assessment will be published on the IRIS database.


U.S. EPA. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/016, 2009.


Jan 1987EPA posted an assessment for cyanide salts (RfD only).
Sep 1994EPA posted an assessment for hydrogen cyanide (RfC only).
Jun 2004The IRIS reassessment of hydrogen cyanide was initiated in 2004.
Sep 2009EPA released an external review draft of the assessment for public review and comment.
Oct 2009EPA announced a public listening session that was held on October 27, 2009 in a September 23, 2009 Federal Register Notice.
Nov 2009EPA announced the details of an external peer review workshop to be held on December 14, 2009 in a November 10, 2009 Federal Register Notice.
Jan 2010EPA released the comments from the public comment period and external review workshop.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2009-0245” (for the docket ID) to comment on this report.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.