State-of-the-Science Workshop Report: Issues and Approaches in Low Dose–response Extrapolation for Environmental Health Risk Assessment
- the need for formalized approaches and criteria to assess the evidence for mode of action;
- the use of human vs. animal data;
- the use of mode of action information in biologically-based models; and
- the implications of interindividual variability, background disease processes and background exposures in threshold vs. nonthreshold model choice.
Workshop goals were to: (1) review the state of the science for high-to-low dose-response extrapolation methods in environmental health risk assessments, (2) identify realistic approaches for the practical application of low-dose extrapolation incorporating the relevant scientific evidence to the fullest extent feasible and (3) identify areas for future work.
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