IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft)

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EPA is releasing the draft report, Toxicological Review of Pentachlorophenol, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

The draft Toxicological Review of Pentachlorophenol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to pentachlorophenol. Pentachlorophenol is a wood preservative used to prevent decay from fungal organisms and insect damage. Use by the public was restricted in 1984, and application was limited to industrial areas. It has been reported in food, surface water, groundwater, rainwater, and soil. People who work or reside in close proximity to wood treatment facilities, treated lumber, or hazardous waste sites are likely exposed.


This assessment has been loaded into the IRIS Web site and Database.


U.S. EPA. IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/004D, 2010.


May 2009EPA released the external review draft report for public review and comment.
Jun 2009EPA announced a public listening session for the draft review report. [Fedral Register Notice Jun 9, 2009]
Jun 2009EPA announced the external peer review meeting to be held August 4, 2009 in Arlington, VA. [Federal Register Notice Jun 29, 2009]
Oct 2009EPA released the comments from the external review workshop and public comment period.
Jul 2010EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Pentachlorophenol .
Sep 2010EPA releases the final report and the interagency science discussion review draft with comments.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.