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Concepts, Methods, and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects: A Resource Document (Final Report)
Federal Register Notices
NoticeEPA announced the release of the final report, Concepts, Methods, and Data Sources for Cumulative Health Risk Assessment of Multiple Chemicals, Exposures and Effects: A Resource Document, in the June 27, 2008 Federal Register Notice.
AbstractThis final report is a resource document that provides concepts, methods and data sources to assist in the conduct of multi-chemical, population-focused cumulative risk assessments. It is not guidance, but rather a presentation of information that could assist in the development of future guidance on cumulative risk assessment. It addresses a subset of issues related to chemical mixtures risk assessment that are identified in the 2003 Framework for Cumulative Risk Assessment. This report focuses on two areas:
- initiating factors for a cumulative risk assessment, with procedures for data collection and organization, and
- technical approaches for assessing human health risks associated with a multiple chemicals, exposures and effects.
- Procedures for population characterization, data collection and data organization based on the initiating factors for a cumulative risk assessment
- A chemical grouping method to scope analyses into manageable pieces to be assessed as multiple chemicals with co-occurring exposures and common toxicity
- Approaches and data sources for evaluating the timing of exposures, including discussions of chemical degradation over time in the environment and of kinetics and dynamics
- Integration of internal dose measurements to account for multiple route exposures
- Estimation of mixture risks for multiple route exposures by calculating route-specific risks using the Relative Potency Factor (RPF) approach and then summing the route-specific RPF-based risks across routes
- Integration of output from multiple effects modeling (illustrated using a categorical regression model) with the Hazard Index (HI) and response addition models to express risks for multiple health effects
- Detail on the cumulative HI approach, including impacts for risk characterization
- Refinement of the interaction-based HI method to account for toxicological interactions
- A method for cumulative risk characterization that considers factors unique to the conduct of a cumulative risk assessment, including uncertainties in cumulative dose-response and exposure assessment
- A general emphasis on integrating exposure and dose-response analysis
- A Risk Assessment Toolbox (Appendix A) that provides numerous sources of data and tools for use in conducting a cumulative risk assessment.
|Feb 2001||NCEA began work developing cumulative risk approaches and information through an Interagency Agreement with the Department of Energy.|
|May 2003||EPA's Risk Assessment Forum releases the 2003 Framework for Cumulative Risk Assessment.|
|Mar 2006||EPA releases the Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effect (External Review Draft) for public review and comment.|
|May 2006||EPA hosts an external peer review workshop for Considerations for Developing Alternative Health Risk Assessment Approaches for Addressing Multiple Chemicals, Exposures and Effect.|
|Jun 2008||EPA releases the final report.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (412 pp, 16 MB, about PDF)