IRIS Toxicological Review of Dichloromethane (Methylene Chloride) (Interagency Science Consultation Draft)
Notice - This site contains archived material(s)
Archive disclaimer
Archive
disclaimer
Archived files are provided for reference
purposes only. These files are no longer maintained by the Agency and may be outdated. For
current EPA information, go to www.epa.gov. It is EPA's policy to
support reasonable accommodation to persons with disabilities, pursuant to the Rehabilitation
Act of 1973, 29 U.S.C. 791. If you need assistance with accessing archived files, contact
EPA's Reasonable Accommodations
or submit a request using the Contact Us form.
Abstract
The draft Toxicological Review of Dichloromethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to dichloromethane. Dichloromethane, also known as methylene chloride, is a colorless liquid. It is, or has been, used principally in paint strippers and removers, as a propellant in aerosols, in the manufacture of drugs, pharmaceuticals, film coatings, electronics, and polyurethane foam, as a metal cleaning solvent, and in the decaffeination process of coffee and tea.
Impact/Purpose
Status
Citation
History/Chronology
Date | Description |
---|---|
1987 | The oral RfD for dichloromethane was posted to the IRIS database. |
1990 | The cancer assessment for dichloromethane was posted to the IRIS database. |
Dec 2009 | EPA initiated an interagency science consultation on the review of the draft Toxicological Review of Dichloromethane. |
Mar 2010 | EPA released an external review draft and the interagency review draft with comments. |
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Dichloromethane (Interagency Science Consultation Draft) (PDF) (367 pp, 3 MB, about PDF)
- Charge to External Peer Reviewers (Interagency Science Consultation Draft) (PDF) (4 pp, 45 KB, about PDF)
- OMB Comments of the Review of Dichloromethane (Dec 2009) (PDF) (10 pp, 65 KB, about PDF)
- ATSDR/NCEH Comments of the Review of Dichloromethane (Jan 2010) (PDF) (1 pp, 32 KB, about PDF)
- DOD Comments of the Review of Dichloromethane (Jan 2010) (PDF) (19 pp, 145 KB, about PDF)
- DOD Comments on the External Peer Review Charge (Jan 2010) (PDF) (10 pp, 48 KB, about PDF)