Toxicological Review of Cyanobacterial Toxins: Anatoxin-a (External Review Draft)
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The Safe Drinking Water Act (SDWA), as amended in 1996, requires the EPA to publish a list of contaminants that, at the time of publication, are not subject to any proposed or promulgated national primary drinking water regulations, are known or anticipated to occur in public water systems, and may require regulations under SDWA. This list, known as the Contaminant Candidate List (CCL), was first published in 1998 and then again in 2005. The 1998 and 2005 CCLs include cyanobacteria (blue-green algae), other freshwater algae, and their toxins as microbial contaminants.
In 2001, a meeting was held among EPA, researchers from the drinking water industry, academia and government agencies with expertise in the area of fresh water algae and their toxins. The goal of this meeting was to convene a panel of scientists to assist in identifying a target list of algal toxins that are likely to pose a health risk in source and finished waters of the drinking water utilities in the U.S. Toxin selection was based on four criteria: health effects, occurrence in the United States, susceptibility to drinking water treatment and toxin stability. Anatoxin-a was identified at this meeting as being a toxin of high priority based on those criteria.
NCEA then prepared the document, Toxicological Review of Cyanobacterial Toxins: Anatoxin-a as one in a series of dose-response assessments to support the health assessment of unregulated contaminants on the CCL. The purpose of this document is to compile and evaluate the available data regarding Anatoxin-a toxicity to aid the EPA/Office of Water in regulatory decision making. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of Anatoxin-a.
|Jul 2006||Internal Review completed and comments addressed.|
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