Dosimetry of Nasal Uptake of Soluble and Reactive Gases: A First Study of Inter-Human Variability (Journal Article)

Anatomically accurate human child and adult nasal tract models will be used in concert with computationally simulated air flow information to investigate the influence of age-related differences in anatomy on inhalation dosimetry in the upper and lower airways. The findings of this research will better characterize available information on human nasal tract dosimetry, including evaluation of the adequacy of the current Agency default dosimetry, especially for the upper airways (i.e., the nasal and nasopharyngeal areas).

Citation

Garcia, G. J., J. D. Schroeter, R. A. Segal, J. J. STANEK, G. L. FOUREMAN, AND J. S. Kimbell. Dosimetry of Nasal Uptake of Soluble and Reactive Gases: A First Study of Inter-Human Variability (Journal Article). INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 21(7):607-618, (2009).