Nitrobenzene Carcinogenicity (1998)
Notice - This site contains archived material(s)
Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please use the contact us form if you need additional support.
No human studies cancer data are available, therefore this analysis is based on a Chemical Industry Institute of Toxicology (CIIT) NB inhalation study. The study involves both sexes of B6C3F1 mice (0, 5, 25, 50 ppm NB) and F344/N rats (0, 1, 5, 25 ppm NB), but only male Sprague-Dawley (CD strain) rats (0, 1, 5, 25 ppm NB). All are exposed at 6 hrs/day, 5 days/wk, for 104 wks. Mouse results show increased benign male tumors in the alveolus, bronchus, and thyroid, whereas female mice indicated mammary cancers. F344/N rats responded with male liver cancer and benign responses in the follicular thyroid and kidney, whereas females had benign endometrial polyps. Male CD rats has benign hepatocellular adenomas. Because NB causes tumorigenicity at 8 sites, 6 organs, both sexes, among 3 test species, NB is classified as a B2 carcinogen or a likely human carcinogen by any route by the proposed EPA Cancer Guidelines (U.S.EPA, 1986).
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (32 pp, 377 KB, about PDF)