IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR XYLENES (EXTERNAL REVIEW DRAFT)
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Abstract
The cancer weight of evidence determination for mixed xylenes is group D- not classifiable as to human carcinogenicity by the Guidelines for Carcinogen Risk Assessment (1986) and data are inadequate for an assessment of human carcinogenic potential due to conflicting evidence by the revised draft Guidelines for Carcinogen Risk Assessment (1999).
There is limited information on the relative toxicity of the individual isomers and the results are inconsistent. Based on available data, there do not appear to be susceptible populations.
Citation
Additional Information
To access or download the external review draft xylenes document and related IRIS Summary, please refer to the Downloads/URL Links on the left sidebar.
Please direct any correspondence to: Michael Broder, National Center for Environmental Assessment (8601D), U.S. EPA, 1200 Pennsylvania Ave., NW, Washington, DC 20460 or to broder.michael@epa.gov. Also, please send a record keeping copy to: IRIS Submission Desk, c/o ASRC, 6301 Ivy Lane, Suite 300, Greenbelt, MD 20770. Note that this is a new address for the Submission Desk., or email to
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- IRIS Summary - Xylenes (External Review Draft) (PDF) (19 pp, 149 KB, about PDF)
- Instructions to Peer Reviewers for Reviewing IRIS Summaries and Supporting Documentation for Xylenes (CAS No. 1330-20-7) (PDF) (4 pp, 91 KB, about PDF)
- Toxicological Review of Xylenes (External Review Draft) The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard identification and dose-response assessment in IRIS pertaining to chronic exposure to xylenes. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of xylenes. (PDF) (74 pp, 375 KB, about PDF)