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Air Quality: EPA's Integrated Science Assessments (ISAs)

Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft)

Notice

EPA is announcing the availability of the First External Review Draft of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria as described in the November 22, 2013, Federal Register Notice.

Report Information

EPA is announcing the availability of the First External Review Draft of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria for public comment and independent peer review. This draft document provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of oxides of nitrogen. When final, it will provide a critical part of the scientific foundation for EPA’s decision regarding the adequacy of the current primary (health-based) national ambient air quality standards for nitrogen dioxide.

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Molini Patel
  • by phone at:   919-541-1492
  • by email at:  patel.molini@epa.gov

Background

Oxides of nitrogen are one of six principal (or criteria) pollutants for which EPA has established national ambient air quality standards (NAAQS). For oxides of nitrogen, the NAAQS are specified in terms of nitrogen dioxide (NO2). The Clean Air Act requires EPA to periodically review the scientific basis for these standards by preparing an Integrated Science Assessment. These reviews play a significant role in EPA’s commitment to ensuring a clean and healthy environment for the public.

The first draft ISA is part of the Agency’s periodic review of the primary (health-based) NAAQS for NO2. Overall, findings from recent studies strengthen the conclusions from the previous NAAQS review, which was completed in 2010. Results from recent studies strengthen the body of evidence indicating that short-term exposure to NO2 can cause respiratory effects, in particular, effects related to asthma exacerbations. Recent results also strengthen the evidence that the respiratory effects of NO2 are independent of the effects of many other traffic-related pollutants. And finally, recent results expand on previous results supporting relationships between short-term exposure to NO2 and cardiovascular effects and premature mortality. There is now stronger evidence for a relationship between long-term exposure to NO2 and respiratory effects, particularly in children.

History/Chronology

Jul 2008EPA released the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Final Report) (EPA/600/R-08/071). [Federal Register Notice Jul 11, 2008]
Mar 2012EPA held a workshop entitled "Kickoff Workshop to Inform EPA's Review of the Primary NO2 NAAQS'" co-organized by EPA/ORD/NCEA and the EPA/OAQPS Staff to help with the development of future products on this subject matter. The workshop was held February 29 - March 1, 2012, in Research Triangle Park, North Carolina. [Federal Register Notice Feb 10, 2012]
May 2013EPA released the draft development plan for the next Integrated Science Assessment (ISA) for health effects of oxides of nitrogen. [Federal Register Notice May 3, 2013]
Jun 2013EPA’s Science Advisory Board’s CASAC announces a June 2013 consultation by the Oxides of Nitrogen Review Panel on the Draft Plan for the Development of the Integrated Science Assessment for Oxides of Nitrogen. [Federal Register Notice May 9, 2013]
Jun 2013EPA held a public workshop to review initial draft materials to inform the development of the upcoming Integrated Science Assessment for Oxides of Nitrogen – Health Criteria. [Federal Register Notice May 10, 2013]
Nov 2013EPA released the first external review draft for public review and comment. [Federal Register Notice November 22, 2013]

Next Steps

This draft will be reviewed by the Clean Air Scientific Advisory Committee (CASAC) at a public meeting in March 2014. A second draft will be released in summer 2014. The second draft will address CASAC and public comments received on the first draft. The final assessment, which will be available on EPA’s website, will provide a critical part of the scientific foundation for EPA’s periodic review and possible revision of the primary NAAQS for nitrogen dioxide.

Additional Information

Included for public review is the draft Integrated Science Assessment for Oxides of Nitrogen - Health Criteria (First External Review Draft). Comments on this document may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the keyword EPA-HQ-ORD-2013-0232 (for the docket ID) to comment on this report.

Citation

U.S. EPA. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-13/202, 2013.

Downloads

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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