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IRIS Toxicological Review of Dichlorobenzenes (2004 External Review Draft)
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Federal Register Notices
Contact
- John C. Lipscomb
- by phone at: 513-569-7217
- by fax at: 513-487-2539
- by email at: lipscomb.john@epa.gov
- by fax at: 513-487-2539
Downloads/Related Links
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- Toxicological Review of Dichlorobenzenes (PDF) (146 pp, 8 MB, about PDF)
- Draft IRIS Summary: 1,2-Dichlorobenzene (PDF) (20 pp, 183 KB, about PDF)
- Draft IRIS Summary: 1,3-Dichlorobenzene (PDF) (15 pp, 159 KB, about PDF)
- Draft IRIS Summary: 1,4-Dichlorobenzene (PDF) (39 pp, 903 KB, about PDF)
- Charge to Reviewers, External Review Draft (PDF) (4 pp, 41 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) 2004 (PDF) (52 pp, 5 MB, about PDF)
- Consolidated Comments from the External Peer Review (1,4 DCB Only) 2006 (PDF) (18 pp, 534 KB, about PDF)
Related Link(s)
- IRIS Toxicological Review of 1,2-Dichlorobenzene (CASRN 95-50-1)
- IRIS Toxicological Review of 1,3-Dichlorobenzene (CASRN 541-73-1)
- IRIS Toxicological Review of 1,4-Dichlorobenzene (CASRN 106-46-7)
Public Comments
EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to the external review panel for EPA's health assessment of 1,2-, 1,3-, and 1,4-dichlorobenzenes. These documents are provided for public viewing during an external scientific peer review period. While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to 03/01/04 will be considered in subsequent drafts.
Background
1,2-Dichlorobenzene is generally used as a chemical intermediate for making agricultural chemicals primarily herbicides, 1,3-dichlorobenzene is used as a fumigant in insecticides and 1,4-dichlorobenzene is used as a space deodorant, moth repellent, and as an intermediate in the synthesis of certain pesticides, dyes and resins. Chemical waste dump leachates and direct manufacturing effluents are reported to be the major source of pollution.
Dichlorobenzene (DCB) was first evaluated by the Environmental Criteria and Assessment Office (ECAO), Office of Research and Development (ORD), Cincinnati, OH in 1987 for non-cancer and cancer endpoints. It was also evaluated by IRIS in 1996 (inhalation RfC; 1,4-DCB), 1992, 1990 (carcinogenicity and oral RfD respectively; 1,3-DCB), and 1991 (carcinogenicity and oral RfD; 1,2-DCB).
Dichlorobenzene (DCB) was first evaluated by the Environmental Criteria and Assessment Office (ECAO), Office of Research and Development (ORD), Cincinnati, OH in 1987 for non-cancer and cancer endpoints. It was also evaluated by IRIS in 1996 (inhalation RfC; 1,4-DCB), 1992, 1990 (carcinogenicity and oral RfD respectively; 1,3-DCB), and 1991 (carcinogenicity and oral RfD; 1,2-DCB).
Next Steps
This draft has been archived.
Citation
U.S. EPA. IRIS Toxicological Review of Dichlorobenzenes (2004 External Review Draft). US Environmental Protection Agency, Cincinnati, OH, EPA/635/R-03/015, 2004.