US EPA

EPA released the draft report,Toxicological Review for Carbon Tetrachloride(Interagency Science Discussion Draft), that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.

U.S. EPA. IRIS Toxicological Review for Carbon Tetrachloride (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/005D, 2010.

Carbon tetrachloride has been used as a dry-cleaning agent, fabric-spotting fluid, solvent, reagent in chemical synthesis, fire extinguisher fluid, and grain fumigant, but its primary use was in chlorofluorocarbon (CFC) production. Production of this chemical peaked in the early 1970s; annual production has generally declined since the mid-1970s. The Consumer Product Safety Commission banned the use of carbon tetrachloride in consumer products in the 1970s. Decline in the use of carbon tetrachloride also accompanied EPA’s increased regulation of the use of CFCs in propellants, and the Montreal Protocol, which was implemented in the U.S. via Title VI of the Clean Air Act Amendments of 1990 and that called for a ban (with certain exemptions) on production and import of carbon tetrachloride.

Date	Description
02-May 2008	EPA released the external review draft for public comment. [Federal Register Notice May 21, 2008]
03-Jun 2008	EPA announced a public listening session on July 16, 2008. [Federal Register Jun 24, 2008 ]
04-Sep 2008	EPA announced the external peer review meeting to be held on October 14, 2008. [Federal Register Sep 9, 2008]
05-Nov 2008	EPA released the comments from the external review workshop.
06-Nov 2009	EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Carbon Tetrachloride.
07-Mar 2010	EPA released the IRIS Toxicological Review and IRIS Summary for Carbon Tetrachloride and the interagency review draft with interagency review comments.

This assessment has been loaded into the IRIS Web site and Database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Carbon Tetrachloride (Interagency Science Discussion Draft) (PDF)  (487 pp, 4 MB, about PDF)
• Carbon Tetrachloride Summary (Interagency Science Discussion Draft) (PDF)  (34 pp, 538 KB, about PDF)
• 1. DOE Carbon Tetrachloride IASD Comments (PDF)  (1 pp, 12 KB, about PDF)
• 2. OMB Carbon Tetrachloride IASD Comments (PDF)  (4 pp, 37 KB, about PDF)

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• IRIS Toxicological Review of Carbon Tetrachloride (External Review Draft)
• IRIS Toxicological Review of Carbon Tetrachloride (Final Report)