US EPA

In August 2018, EPA finalized the IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX). The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices in May 2018. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including the interagency review draft are posted on this site.

U.S. EPA. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-18/065, 2018.

Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX, or Royal Demolition eXplosive) is a military explosive with limited civilian uses. In the United States, RDX is produced at Army munitions plants; it is not produced commercially.

Date	Description
02-Dec 2013	EPA discussed preliminary draft materials at the December 12-13, 2013 IRIS Bimonthly Public Meeting. Presentations are also available on the meeting web site.
03-Mar 2016	EPA released the public comment draft for a 60-day review period and announced it will be discussed at the May 10, 2016 IRIS Public Science Meeting. EPA also released the interagency science consultation documents, comments from reviewers, and EPA's response to major comments. [Federal Register Notice: Mar 10, 2016]
04-Mar 2016	EPA announced a request for nominations of experts to augment the SAB CAAC for the review of the draft RDX assessment. Any related questions should be directed to the SAB. [SAB Federal Register Notice Mar 18, 2016]
05-May 2016	EPA discussed the draft RDX Toxicological Review at the May IRIS Public Science Meeting.
06-Sep 2016	EPA released the external review draft for peer review by EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC). Any related questions should be directed to the SAB. [SAB Federal Register Notice Sep 29, 2016]
07-Dec 2016	EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) convened a 3-day meeting to conduct a peer review of the draft Toxicological Review.
08-Apr 2017	EPA's Science Advisory Board (SAB) held a 2-day public external peer review teleconference to discuss the draft Toxicological Review. [Federal Register Notice Mar 22, 2017]
09-May 2018	EPA submitted a revised draft for final Agency Review and Interagency Science Discussion.
10-Aug 2018	EPA posted the final IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) and summary to the IRIS database.

The RDX assessment has been loaded into the IRIS website and database.

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Interagency Science Discussion Draft) (PDF)  (179 pp, 3 MB, about PDF)
• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Interagency Science Discussion Draft) Supplemental Information (PDF)  (208 pp, 3 MB, about PDF)
• 1. DoD Comments on Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (PDF)  (3 pp, 33 KB, about PDF)
• EPA’s Response to Interagency Comments (PDF)  (2 pp, 148 KB, about PDF)

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• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Preliminary Assessment Materials)
• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Public Comment Draft)
• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Interagency Science Consultation Draft)
• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (External Review Draft)
• IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (Final Report)