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IRIS Toxicological Review and Summary Documents for Hydrogen Sulfide (External Review Draft)

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Gary L. Foureman
by phone at:   919-541-1183
by fax at:   919-541-1818
by email at:  foureman.gary@epa.gov
Hydrogen sulfide (H2S) is a colorless gas with a strong odor of rotten eggs. Its primary uses include the production of elemental sulfur and sulfuric acid, the manufacture of heavy water and other chemicals. Occupational exposure occurs primarily from its presence in petroleum, natural gas, soil, sewer gas and as a byproduct of chemical reactions. Case reports involving accidental overexposure to H2S have resulted in neurotoxicity, pulmonary edema, respiratory paralysis and, in many instances, death. Levels associated with incapacitation and death may occur around 500 ppm (695 mg/m3) and above. Limited epidemiological studies have described cardiovascular, pulmonary, and ocular effects. The lack of adequate monitoring data preclude the identification of more precise cause-effect levels for acute or chronic exposure scenarios.

Subchronic inhalation of H2S has been shown to mainly affect the nasal mucosa in laboratory animals and been reported to increase seminiferous tubular degeneration and epididymal changes in rats exposed to 80 ppm (111 mg/m3) H2S. Three subchronic animal studies were considered for derivation of an inhalation RfC: the study by Brenneman et al. (2000) was considered to be the best study for derivation of an inhalation RfC. Nasal lesions were identified as the critical effects. Application of the RfC methodology yielded a NOAEL of 10 ppm (14 mg/m3) and a LOAEL of 30 ppm (42mg/m3). The LOAEL and NOAEL were then converted to continuous exposure by means of a dosimetric adjustment factor derived from the regional gas dose ratio (RGDR) for H2S in the extrathoracic (ET) region. The animal NOAEL is then multiplied by the RGDRET to yield the NOAELHEC. The RfC was derived by dividing the NOAELHEC for nasal effects by a total uncertainty factor of 300, yielding an inhalation RfC of 0.002 mg/m3 or 1 ppb. No data pertaining to the potential carcinogenicity of H2S were identified.

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This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Public Comments

The U.S. Environmental Protection Agency (EPA) is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of hydrogen sulfide (CAS No. 7783-06-4). While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to April 4, 2002, will be considered in subsequent drafts.

Please direct any correspondence to: Gary Foureman, National Center for Environmental Assessment-RTP Office (MD-52), U.S. EPA, Research Triangle Park, NC 27711, or to foureman.gary@epa.gov. Also, please send a record keeping copy to: IRIS Submission Desk, c/o ASRC, 6301 Ivy Lane, Suite 300, Greenbelt, MD 20770. Note that this is a new address for the Submission Desk., or email to

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