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IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.


Contact
Norman Birchfield
by phone at:   703-347-0174
by fax at:   703-347-8699
by email at:  birchfield.norman@epa.gov
On June 26, 2012, the draft Toxicological Review of Trimethylbenzenes and the draft charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science consultation materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Trimethylbenzenes and the charge to external peer reviewers, are posted on this site.

Downloads/Related Links
Background
Trimethylbenzenes (TMB) are a mixture of three isomers: 1,2,3-, 1,2,4- and 1,3,5-TMB. TMBs are produced during petroleum refining, and 1,2,4-TMB makes up approximately 40% of a certain petroleum product (the C9 fraction) which is used as a component of gasoline. Because of this, vehicle emissions are a major source of TMBs. Other uses of TMBs include solvents in research and industry, dyestuff intermediate, paint thinner, and as a UV oxidation stabilizer for plastics.

History/Chronology

Feb 2012EPA hosted an interagency science consultation meeting on the review of the draft Toxicological Review of Trimethylbenzenes.
May 2012EPA sent an abbreviated version of the toxicological review containing only information on 1,2,3-trimethylbenzene for Interagency Science Consultation at the recommendation of reviewers.
Jun 2012EPA released the external peer review draft of the trimethylbenzenes assessment for public review and comment.

Next Steps

Following external peer review and public comment, the assessment will be revised taking into consideration the comments received. It will then undergo a final internal review by EPA and other federal agencies and White House offices. After completing the review it will be posted to the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/012C, 2012.

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