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IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft)
Contact
- Norman Birchfield
- by phone at: 703-347-0174
- by fax at: 703-347-8699
- by email at: birchfield.norman@epa.gov
- by fax at: 703-347-8699
Downloads/Related Links
- IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft) (PDF) (136 pp, 1 MB, about PDF)
- Charge to External Peer Reviewers (PDF) (2 pp, 29 KB, about PDF)
- EPA's Response and Comments from the Interagency Science Consultation (PDF) (12 pp, 85 KB, about PDF)
Related Link(s)
Background
The draft Toxicological Review of n-butanol provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to n-butanol. n-Butanol is widely used as an organic solvent and is an intermediate in the manufacture of other organic chemicals such as acetates, acrylates and glycol ethers. n-Butanol is also a natural component of many foods and formed during the fermentation of carbohydrates.
History/Chronology
| Mar 1987 | A RfD was posted for n-butanol to the IRIS Database. |
| Mar 1991 | The cancer assessment for n-butanol was posted to the IRIS Database. |
| Jun 2011 | EPA initiated the interagency science consultation on the draft Toxicological Review of n-Butanol. |
| Sep 2011 | EPA released the External Review Draft for public review and comment. |
Next Steps
Following external peer review the assessment will be revised taking into consideration external peer review and public comments. The revised assessment will undergo a final EPA internal review and review by other federal agencies and White House offices, then the final assessment will be posted to the IRIS database.
Citation
U.S. EPA. IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/081C, 2011.