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IRIS Toxicological Review of Urea (External Review Draft)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.


Contact
Amanda Persad
by phone at:   919-541-9781
by fax at:   919-541-2985
by email at:  persad.amanda@epa.gov
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Urea that when finalized will appear on the Integrated Risk Information System (IRIS) database.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Public Comments

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2010-0633" (for the docket ID) to comment on this report.

Background
The draft Toxicological Review of Urea provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to Urea. Urea, also known as carbamide, is an endogenous product of protein and amino acid catabolism. It can also be produced synthetically by combining ammonia, carbon monoxide, and sulfur in methanol. Urea is utilized in diesel selective catalyst reduction, in fertilizers and animal feed, plastics, flame-proofing agents, adhesives, flavoring agents and consumer goods such as liquid soaps, detergents and household cleaning products.

History/Chronology

Jun 2010EPA initiated the interagency science consultation on the draft Toxicological Review of Urea.
Sep 2010EPA released the External Review Draft for public review and comment and the interagency science consultation review draft with comments. [Federal Register Sep 28, 2010]
Nov 2010EPA announced the external peer review meeting to be held on December 13, 2010 via teleconference. [Federal Register Nov 10, 2010]
Jan 2011EPA releases the comments from the public comment period and external review workshop.

Next Steps

Following external peer review and public comment, the final assessment will be posted to the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of Urea (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-10/005A, 2010.

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