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IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)
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Contact
- Norman Birchfield
- by phone at: 703-347-0174
- by fax at: 703-347-8699
- by email at: birchfield.norman@epa.gov
- by fax at: 703-347-8699
Downloads/Related Links
- Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft) (PDF) (171 pp, 1 MB, about PDF)
- Cis-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF) (12 pp, 80 KB, about PDF)
- Trans-1,2-DCE Summary (Interagency Science Discussion Draft) (PDF) (17 pp, 116 KB, about PDF)
- Cis and Trans Dichloroethylene ATSDR Comments (PDF) (2 pp, 43 KB, about PDF)
- Cis and Trans Dichloroethylene CEQ Comments (PDF) (2 pp, 47 KB, about PDF)
- Cis and Trans Dichloroethylene DoD Comments (PDF) (10 pp, 84 KB, about PDF)
- Cis and Trans Dichloroethylene OMB Comments (PDF) (2 pp, 23 KB, about PDF)
Related Link(s)
- IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (2010 Final)
- IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)
- IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
Background
The draft Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.
History/Chronology
| Sep 1988 | EPA released the assessment for trans-1,2-dichloroethylene (RfD only). |
| Dec 1990 | EPA released the assessment for cis-1,2-dichloroethylene (qualitative cancer assessment only). |
| Aug 2009 | EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene. |
| Sep 2009 | EPA released an external review draft of the assessment for public review and comment. |
| Nov 2009 | EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009] |
| Jan 2010 | EPA releases the comments from the external review workshop and public comment period. |
| Jul 2010 | EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene . |
| Sep 2010 | EPA releases the final report and IRIS Summary and the interagency review draft with comments.. |
Next Steps
Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.
Citation
U.S. EPA. IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006D, 2010.