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IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010)
Federal Register Notices
EPA announces the release of the Toxicological Review of Formaldehyde-Inhalation Assessment in the June 2, 2010 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 90 days after the release of the FRN will be provided to the National Academy of Sciences (NAS) independent scientific peer review committee for its consideration. Any comments not received within the requested time period will be considered by EPA in revisions. This FRN also includes notice of a public listening session that was held on July 27, 2010.
UPDATE EPA is currently revising its Integrated Risk Information System (IRIS) assessment of formaldehyde to address the 2011 NAS peer review recommendations. This assessment addresses both noncancer and cancer human health effects that are relevant to assessing the risks from chronic inhalation exposure to formaldehyde. To facilitate discussion of several scientific issues pertinent to the assessment, EPA convened a state-of-the-science workshop on April 30 and May 1, 2014. This workshop focused on the following three themes:
- Evidence pertaining to the influence of formaldehyde that is produced endogenously (by the body during normal biological processes) on the toxicity of inhaled formaldehyde, and implications for the health assessment;
- Mechanistic evidence relevant to formaldehyde inhalation exposure and lymphohematopoietic cancers (leukemia and lymphomas); and
- Epidemiological research examining the potential association between formaldehyde exposure and lymphohematopoietic cancers (leukemia and lymphomas).
|Sep 1990||The oral RfD for formaldehyde was posted to the IRIS database.|
|May 1991||The cancer assessment for formaldehyde was posted to the IRIS database.|
|Jan 1998||EPA begins the formaldehyde reassessment under the IRIS Program.|
|May 2010||EPA initiated an interagency science consultation on the review of the draft Toxicological Review of formaldehyde.|
|Jun 2010||EPA released an external review draft of the formaldehyde reassessment for public review and comment. Also released was the interagency review draft with comments.|
|Jun 2010||National Academy of Sciences (NAS) conducted an external peer review meeting to review the draft document on Jun 7-8, 2010 in Washington DC.|
|Jul 2010||NAS held their second external review meeting to discuss the draft report on July 6, 2010.|
|Aug 2010||NAS held their third external review meeting to discuss the draft report on Aug 9-10, 2010 in Washington, DC.|
|Oct 2010||NAS held their fourth external review meeting to discuss the draft report on Oct 12-13, 2010 in Washington, DC.|
|Dec 2010||NAS held their fifth and final external review meeting to discuss the draft report on Dec 13-14, 2010 in Los Angelos, CA.|
|May 2011||NAS's Board on Environmental Studies and Toxicology (BEST) releases the NAS Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde (Final Report).|
|Apr 2014||EPA convened a state-of-the-science workshop on formaldehyde on April 30 and May 1, 2014 in Arlington, VA. This workshop focused on 3 themes, see the web site for specific details.|
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.