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IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)

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Contact
Weihsueh Chiu
by phone at:   703-347-8607
by email at:  chiu.weihsueh@epa.gov
EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database. Please refer to IRISTrack - Trichloroethylene for the latest schedule updates.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Public Comments

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0791 (for the docket ID).

Instructions for accessing supplementary files to Appendices A, F, and G.
(1) Download "Appendix_linked_files.zip" file.
(2) "Extract" files using Microsoft Windows or equivalent decompression software, creating a folder named "Appendix.linked.files"
(3) Move the folder "Appendix.linked.files" to the same directory where the PDF file for Appendix A, F, or G is located.
(4) Open the PDF file for Appendix A, F, or G using Adobe Acrobat Reader. To open the supplementary files, click on the appropriate links.


Background
The draft Toxicological Review of Trichloroethylene (TCE) provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to TCE. TCE is a chlorinated solvent that has been widely used as a metal degreaser, as a chemical intermediate and extractant, and as a component of some consumer products. TCE is designated as a Hazardous Air Pollutant, is a common groundwater contaminant, and has been found at more than 1,500 hazardous waste sites. TCE enters the atmosphere from vapor degreasing operations or volatilization from contaminated soils, surface waters via direct discharges, and groundwater through leaching from disposal operations and hazardous waste sites. In addition, TCE can be released to indoor air from the use of TCE-containing consumer products, volatilization from water supplies, and vapor intrusion through walls and floors from contaminated soil and groundwater.

History/Chronology

Aug 2001EPA released an external review draft, Trichloroethylene Health Risk Assessment: Synthesis and Characterization for public review and comment.
Dec 2002EPA's Science Advisory Board (SAB) released an independent peer review report Review of Draft Trichloroethylene Health Risk Assessment: Synthesis and Characterization: An EPA Science Advisory Board Report (PDF, 83 pp, 376 KB, about PDF).
Feb 2004EPA hosts a Symposium on New Scientific Research Related to the Health Effects of Trichloroethylene held in Washington, DC.
Sep 2004The National Academy of Science (NAS) initiated the project “Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues” under sponsorship of EPA and other federal agencies.
Feb 2005EPA submitted four TCE issue papers on key scientific issues to the NAS.
July 2006NAS released the report Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues Consultation.
Nov 2009EPA released the draft Toxicological Review of Trichloroethylene (TCE) for public review and comment. Additionally, as per the new IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCE draft report have also been released. [Federal Register Nov 3, 2009]
Dec 2009EPA announced a listening session to be held on January 26, 2010 in the Federal Register Dec 21, 2009, more details can be found in Federal Register Dec 11, 2009.
Jan 2010SAB released the names and biosketches of the "Short List Candidates" for the upcoming TCE Review Panel.
Mar 2010SAB hosted two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (4/20/10) and a face-to-face meeting (5/10-12) to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Mar 31, 2010]
Jun/Jul 2010EPA's SAB announced two public meetings of the SAB Trichloroethylene (TCE) Review Panel: a teleconference (6/24/10) and another teleconference (9/13/10) to discuss the review of EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Jun 2, 2010, Federal Register Jul 27, 2010]
Dec 2010SAB hosted a public meeting of the SAB Trichloroethylene (TCE) Review Panel: by two teleconferences held on 12/15-16/10 to review EPA's Toxicological Review of Trichloroethylene (External Review Draft). [Federal Register Nov 24, 2010]
Jan 2011SAB released the final report, Review of EPA's Draft Assessment entitled "Toxicological Review of Trichloroethylene. (PDF, 68 pp., 407,129 bytes), EPA-SAB-11-002

Next Steps

Following external peer review the assessment will be revised taking into consideration external peer review and public comments, will undergo a final EPA internal review and a review by and science discussion with other federal agencies and White House offices, and will be posted to the IRIS database.

The final Trichloroethylene IRIS document is expected to be publicly available during the 4th quarter of FY 2011.

Citation

U.S. EPA. IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/011A, 2009.

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