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IRIS Toxicological Review of Chlordecone (Interagency Science Discussion Draft)
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Contact
- Karen A. Hammerstrom
- by phone at: 703-347-8642
- by email at: hammerstrom.karen@epa.gov
Downloads/Related Links
- Toxicological Review of Chlordecone (Interagency Science Discussion Draft) (PDF) (183 pp, 2 MB, about PDF)
- IRIS Summary for Chlordecone (Interagency Science Discussion Draft) (PDF) (19 pp, 259 KB, about PDF)
- OMB Comments of the IRIS Summary and Toxicological Review of Chlordecone (Interagency Science Discussion Drafts) (PDF) (1 pp, 21 KB, about PDF)
Related Link(s)
Background
The draft Toxicological Review of chlordecone provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to chlordecone. Chlordecone is a chlorinated insecticide which was used mainly as a fungicide and insecticide to control slugs, snails, and fire ants. According to the CERCLA database, chlordecone is found at 3 National Priority List (NPL) Superfund sites. Intoxication occurred in over a hundred workers at a Hopewell, Virginia, chlordecone manufacturing plant in the late 1970s. Effects observed in the workers following this accident included tremors, liver enlargement, and oligospermia (low semen volume). Registration was cancelled in 1978.
History/Chronology
| 2004 | EPA began developing the Toxicological Review of chlorodecone. |
| Jan 2008 | EPA released an External Review Draft for public comment and review. |
| Aug 2009 | EPA hosted an interagency science discussion on the draft IRIS Summary and Toxicological Review of chlordecone. These comments are provided on this web site. |
| Sep 2009 | EPA released the Final Toxicological Review (PDF) and accompanying Summary for chlordecone to the IRIS Web site. |
Next Steps
The assessment has been finalized and loaded onto the IRIS database.
Citation
U.S. EPA. IRIS Toxicological Review of Chlordecone (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, D.C., 2009.