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IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft)

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Contact
Karen A. Hammerstrom
by phone at:   703-347-8642
by email at:  hammerstrom.karen@epa.gov
On September 30, 2009, the IRIS Summary and Toxicological Review of 1,2,3-trichloropropane (TCP) was finalized and loaded onto the IRIS database. The Toxicological Review of TCP was reviewed internally by EPA, by other federal agencies and White House Offices, by expert external peer reviewers, and by the public. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCP IRIS assessment are posted on this site.

Downloads/Related Links
Background
The draft Toxicological Review of 1,2,3-Trichloropropane provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane. 1,2,3-Trichloropropane is an important industrial chemical used as a solvent for oils and fats, waxes, and resins, and has also been used in paint thinner and varnish remover and as a degreasing agent. 1,2,3-Trichloropropane is also generated as a by-product of the production of other chlorinated compounds such as epichlorohydrin, and is used as an intermediate in the production of some pesticides and polymers, such as polysulfide rubbers.

This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.

History/Chronology

2003EPA began developing the Toxicological Review of 1,2,3-trichloropropane.
Nov 2007EPA released an External Review Draft for public comment and review.
Jan 2008EPA announced the external peer review panel meeting in a Jan 18, 2008 Federal Register Notice.
Sep 2009EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of 1,2,3-trichloropropane. These comments are provided on this web site.
Sep 2009EPA released the Final Toxicological Review (PDF) (247 pp, 1.9M) and accompanying Summary for 1,2,3-Trichloropropane to the IRIS Web site.

Next Steps

The assessment has been finalized and loaded onto the IRIS database.

Citation

U.S. EPA. IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, D.C., 2009.

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