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IRIS Process (2008)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.


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Technical Information Staff
by phone at:   703-347-8561
by fax at:   703-347-8691
by email at:  nceadc.comment@epa.gov
The Integrated Risk Information System (IRIS) is a U.S. Environmental Protection Agency (EPA) database that contains information on human health effects that may result from exposure to chemical substances in the environment. IRIS is maintained by EPA’s Office of Research and Development.

The IRIS process consists of development of a draft Toxicological Review for the chemical, internal and external scientific reviews of the draft document, EPA responses to review comments, and development and posting on the IRIS web site of an IRIS Summary and final Toxicological Review. EPA is announcing revisions to the IRIS process. New steps in the process include increased participation by other federal agencies and the public in the development of the Toxicological Review and opportunities for other federal agencies to conduct research to fill data gaps.

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